Whole genome association study of brain-wide imaging phenotypes for identifying quantitative trait loci in MCI and AD: A study of the ADNI cohort
A genome-wide, whole brain approach to investigate genetic effects on neuroimaging
phenotypes for identifying quantitative trait loci is described. The Alzheimer's Disease
Neuroimaging Initiative 1.5 T MRI and genetic dataset was investigated using voxel-based
morphometry (VBM) and FreeSurfer parcellation followed by genome-wide association
studies (GWAS). One hundred forty-two measures of grey matter (GM) density, volume, and
cortical thickness were extracted from baseline scans. GWAS, using PLINK, were performed …
phenotypes for identifying quantitative trait loci is described. The Alzheimer's Disease
Neuroimaging Initiative 1.5 T MRI and genetic dataset was investigated using voxel-based
morphometry (VBM) and FreeSurfer parcellation followed by genome-wide association
studies (GWAS). One hundred forty-two measures of grey matter (GM) density, volume, and
cortical thickness were extracted from baseline scans. GWAS, using PLINK, were performed …
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